• From an historical perspective ligands for GPCRs

  2022-11-18

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, lasofoxifene sale or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligan

• br The pathogenesis of AD and the

  2022-11-18

  

  The pathogenesis of AD and the targets of apelin Alzheimer's drugs Conclusions Introduction APJ, first identified from a human genomic library in 1993, belongs to a member of seven trans-membrane G protein-coupled receptor family. Its amino Lurasidone HCl sequence has 31% homology with

• tranylcypromine Introduction It has long been recognized

  2022-11-18

  

  Introduction It has long been recognized that angiogenesis is critical to the growth, progression, and metastasis of many solid tumor types [1], and thus, drugs targeting the angiogenic pathway have been a topic of clinical investigation in the oncology community for many years. Angiogenesis is reg

• Other reports however have indicated that all components of

  2022-11-18

  

  Other reports, however, have indicated that all components of RAS are produced within the central nervous system (CNS) (Saavedra, 2005). Thus, AGTR1 and AGTR2 in circumventricular organs and in cerebrovascular endothelial cells may respond to circulating ANG2 of peripheral origin, whereas neural rec

• 2510 Finally intracrine androgen synthesis metabolism can be

  2022-11-18

  

  Finally, intracrine androgen synthesis/metabolism can be activated thus allowing 2510 to bypass the low levels of androgens in the circulation by producing androgens themselves (Cai and Balk, 2011, Rahman et al., 2004). Moreover, changes in AR co-regulators like the overexpression of steroid recept

• The rescue of the behavioral deficit was associated with

  2022-11-18

  

  The rescue of the behavioral deficit was associated with a significant reduction in the levels of both soluble and insoluble Aβ peptides and their deposition in the pd0332991 of the same animals. In search for the mechanism behind the reduced amyloidosis, we assessed APP metabolism. Confirming prev

• Dose Response Studies Against Puromycin Sensitive Aminopepti

  2022-11-18

  

  Dose–Response Studies Against Puromycin–Sensitive Aminopeptidase (PSA). PSA is a ubiquitous metallopeptidase encoded by the NPEPPS gene with subcellular distribution in the cytosol and nucleus [49]. Comprising of a 919 amino Obeticholic Acid sequence, it has a broad substrate specificity, and is re

• Salvia the largest genus in the family Lamiaceae

  2022-11-18

  

  Salvia, the largest genus in the family Lamiaceae, comprises over 900 species that are distributed globally [14], [15], [16]. The genus Salvia has been assessed in many studies because it is a rich source of polyphenol compounds, of which more than 160 have been isolated from plants in the genus, so

• When added to the culture medium extracellular ATP is metabo

  2022-11-18

  

  When added to the culture medium, extracellular ATP is metabolized into adenosine by ectonucleotidases, and ARs are then activated by adenosine with concentrations in the micromolar range [27]. However, our study showed that activation of ARs by exogenous adenosine could not induce the odontoblastic

• The enzyme plays an important role

  2022-11-18

  

  The enzyme plays an important role in the purine metabolism of this parasite. Like other parasitic protozoa, T. gondii is incapable of de novo purine biosynthesis and depends totally on preformed purines salvaged from the host NSC 66811 for its purine requirements and survival (Perrotto et al., 197

• Molecular docking is widely used to predict the interaction

  2022-11-17

  

  Molecular docking is widely used to predict the interaction between an enzyme and its inhibitors. This is a computational simulation approach that can be used as a tool to investigate the structure-activity relationship of ACE inhibitory peptides (Goodsell, 2009). It has been recently shown that ACE

• br Conflict of interest br

  2022-11-17

  

  Conflict of interest Acknowledgments Introduction Inflammation is a protective response of the microcirculation to harmful stimuli. Yet, excessive inflammation is potentially harmful and a characteristic of many chronic diseases [1]. 5-Lipoxygenase (5-LO, EC1.13.11.34) contributes to the in

• Although plant Aurora kinases can

  2022-11-17

  

  Although plant Aurora kinases can be clearly grouped into functional clades, the roles of the respective clades does not seem to be evolutionarily conserved. AtAurora 1 labels kinetochore microtubules [19], similarly to mammalian Aurora A, while its targeting to the cell plate resembles features of

• As previously mentioned when hypoxia treated cells

  2022-11-17

  

  As previously mentioned when hypoxia-treated cells become re-oxygenated they sustain a significant amount of DNA damage which has been attributed to the formation of reactive oxygen species . This finding represents more than just an interesting in vitro phenomenon as within a tumor, cells have been

• Apelin induced G i activation has been demonstrated as

  2022-11-17

  

  Apelin induced Gαi activation has been demonstrated as a benefiting effect on cardiac contractility [12], [38], [39], and a vasodilator activity that protects against angiotensin-II-induced cardiovascular fibrosis and atheroma [40], [41]. In contrast, stretch causes hypertrophy through diminishing G

14417 records 319/962 page Previous Next First page 上5页 316317318319320 下5页 Last page