• Abn CBD induced changes reduced microglial

  2022-03-03

  

  Abn-CBD induced changes (reduced microglial cell density, blt2 size and a lower density of ramification) in the microglial morphology that could be compatible with a blockade of the neuroinflammation provoked by MPTPp. The absence of GPR55 transcripts in microglial cells in striatum and the similar

• Adenosine triphosphatase ATP is a signaling molecule in

  2022-03-03

  

  Adenosine triphosphatase (ATP) is a signaling molecule in acute pain and chronic pain(Burnstock, 2009, Burnstock, 2013, Burnstock, 2014, Chizh and Illes, 2001). It is also known that presynaptic A1 receptors are involved in the inhibition of transmitter release (Vizi and Knoll, 1976). Extracellular

• br The methyl aspartate receptor NMDAr hypofunction hypothes

  2022-03-03

  

  The -methyl--aspartate receptor (NMDAr) hypofunction hypothesis of schizophrenia correlates disease symptomology with glutamatergic neurotransmission dysfunction., , , Therefore, inhibition of glycine transporter 1 (GlyT1) to elevate synaptic levels of glycine and potentiate NMDAr signaling is a p

• Sepsis was defined as a systemic inflammatory response syndr

  2022-03-03

  

  Sepsis was defined as a systemic inflammatory response syndrome (SIRS) associated with severe infection in 1992 [9]. However, in the Third International Consensus Definitions for Sepsis and Septic Shock [10], it was redefined as life-threatening organ dysfunction provoked by a dysregulated host resp

• With taurine or other molecules that

  2022-03-03

  

  With taurine, or other molecules that might be transported by Eaat2, an important area of research will be how such a chemical regulates sleep. Indeed, taurine has been described to act on the nervous system in disparate ways — it can act as an inhibitory neurotransmitter, but also has a well-charac

• br Redox regulation in the brain

  2022-03-03

  

  Redox regulation in the brain Reactive oxygen species are generated in SC 79 by the mitochondrial respiratory chain, which occurs on the inner mitochondrial membrane (Murphy, 2009, Jensen, 1966, Dickinson and Chang, 2011). Interestingly, although most cancer cells are thought to primarily rely o

• br Materials and Methods br Results br

  2022-03-02

  

  Materials and Methods Results Discussion In the present study, we investigated the postnatal expression of the two GABA receptor subunits, GABAAα1 and GABAB1, in order to determine the differential expression and regional distribution pattern of them between right and left hippocampi in th

• In general the FDP gene is involved in

  2022-03-02

  

  In general the FDP gene is involved in isoprenoid biosynthesis for normal growth and development of plant species while it is specifically involved in rubber biosynthesis (cis-1,4-polyisoprene units) in Hevea plant. When the HbFDP gene was over-expressed under the control of constitutive promoter in

• Occupying at least of brain volume astroglial cells

  2022-03-02

  

  Occupying at least 50% of 7ACC1 synthesis volume, astroglial cells not only possess a high level of association in network through gap junctions and direct intercellular communications [28], but also are extensively exposed to extracellular fluid and contribute in shaping different types of synapses

• The effect of combined A and PD treatment on

  2022-03-02

  

  The effect of combined A-192621 and PD 155080 treatment on the Methylprednisolone Sodium Succinate during endotoxin infusion is quite different compared to either drug used alone (Wanecek et al., 1999). After administration of both antagonists in combination, cardiac index increased to baseline val

• Cilomilast br HER proto oncogene The erbB gene located

  2022-03-02

  

  HER2 proto-oncogene The erbB2 gene, located on the short arm of chromosome 17, was discovered and cloned in 1983 (Fig. 1) (Sato et al., 1983). The product of this gene, HER2, is a transmembrane glycoprotein of 185 KDa that consists of three main domains: an extracellular, a transmembrane and an i

• Anti apoptotic Bcl proteins have

  2022-03-01

  

  Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients wi

• The characterization of Da CTSL shows

  2022-03-01

  

  The characterization of Da-CTSL1 shows that it preferentially cleaves Z-FR-AFC (Fig. 8), which has a Ciclopirox ethanolamine phenylalanine at P2 and Da-proCTSL1 is autocatalyzed at pH 8.0 releasing an activated Da-CTSL1 that exhibits optimal activity at pH 8 indicating that the enzyme when secreted

• GSTP has an antiapoptotic activity

  2022-03-01

  

  GSTP1 has an antiapoptotic activity that is mediated by the inhibitory interaction with JNK1. Our data suggest that GSTP1 treatment is associated with a significant down-regulation of caspase expression. This might explain the reduction in infarct-related cardiomyocyte death and saving the cardiomyo

• Acknowledgment br Main Text From birth to adulthood humans p

  2022-03-01

  

  Acknowledgment Main Text From birth to adulthood, humans progressively acquire and maintain a complex microbial ecosystem at various body sites and cavities. Early on, these microorganisms establish a complex relationship with the host, resulting in the modulation of several biological functions

14449 records 444/964 page Previous Next First page 上5页 441442443444445 下5页 Last page