• The fine interplay among post translational

  2021-12-28

  

  The fine interplay among post-translational modifications and intersection with other pathways, such as PI3K–AKT, has a crucial role in the regulation of GLI activity and in the generation of their repressor forms 40, 41, 42. In addition to β-TrCP, for example, other E3 ligases belonging to the real

• Adenosine Some previous findings indicate that GALP has an

  2021-12-27

  

  Some previous findings indicate that GALP has an influence on AVP and OT secretion from the posterior pituitary gland. Cunningham et al. (2004) noted that the expression of GALP mRNA was increased in the neurohypophysis of lactating rats compared to non-lactating rats, whereas GALP mRNA expression i

• Production of reactive oxygen species

  2021-12-27

  

  Production of reactive oxygen species (ROS) at the site of pathogen attack following recognition of pathogen-associated molecular patterns (PAMPs) is regarded as one of the initial plant immune responses. ROS accumulation can induce a hypersensitive reaction in host plants, thereby causing programme

• br Materials and methods br Results br Discussion Serum

  2021-12-27

  

  Materials and methods Results Discussion Serum HBsAg is not only an important serological marker for the screening and diagnosis of HBV infection but also an important indicator for the treatment of hepatitis B [15]. Jaroszewicz et al. [4] and Nguyen et al. [8] reported that the HBsAg level

• Introduction In the s nitric oxide NO was first characterize

  2021-12-27

  

  Introduction In the 1980s, nitric oxide (NO) was first characterized as critical to both innate immunity and endogenous signaling in animals [[1], [2], [3], [4], [5]]. NO was the first gaseous signaling molecule synthesized by animals to have its biochemical signaling pathway fully described [2]. P

• br Amino acid usage in cancer br Perspective High

  2021-12-27

  

  Amino neurokinin receptor antagonist usage in cancer Perspective High glucose consumption is a common feature of several types of tumor cells. Therefore, so far, in vivo positron emission tomography (PET) imaging with the glucose analog 18F-fluorodeoxyglucose (18F-FDG) has been used to detect

• Beside its role in NF B and IL activation

  2021-12-27

  

  Beside its role in NF-κB and IL-1β activation, the NRLP3 pathway is closely involved in another essential pathophysiologic mechanism such as the cellular calcium homeostasis. Full activation of the NRLP3 inflammasome requires decreased extracellular K concentrations resulting in decreased osmotic pr

• Imipramine hydrochloride br Acknowledgments br Introduction

  2021-12-27

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the Imipramine hydrochloride of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann c

• PF-03084014 br Acknowledgments br Introduction Manipulating

  2021-12-27

  

  Acknowledgments Introduction Manipulating target protein expression via either induction or suppression of gene expression is a powerful technology that has been widely used in the recent past in the field of neurobiology, both to study the pathophysiological significance of a target gene and

• Overall ABC transporters are hypothesised to prevent the pen

  2021-12-27

  

  Overall, ABC transporters are hypothesised to prevent the penetration of AEDs and other pharmacological compounds into the brain, being a hurdle for therapeutic delivery in neurological diseases. DRE is thought to be in part related to an increased expression of efflux transporters in the BBB, altho

• Several studies have shown that regulation of glutamate home

  2021-12-27

  

  Several studies have shown that regulation of glutamate homeostasis is critical in relapse to many drugs of abuse [84,85]. Glutamate is transported by GLT-1, which accounted for about 90% of glutamate clearance from the synaptic cleft [14,15]. CEF is known to produce its effects through GLT-1 upregu

• To support maximal growth and metabolic function of

  2021-12-27

  

  To support maximal growth and metabolic function of major organs, glucose and Nitazoxanide are essential. We assessed the plasma levels of glucose and amino acids in LBW and NBW piglets at birth and at day 7 postpartum. Blood glucose levels were influenced by birthweight and age. In this study, the

• Receptors for glucagon Gcgr GLP Glp r and GLP

  2021-12-27

  

  Receptors for glucagon (Gcgr), GLP-1 (Glp1r), and GLP-2 (Glp2r) are G-protein coupled receptors (GPCRs) belonging to class B-1 (secretin receptor-like) family of GPCRs (Harmar, 2001, Fredriksson et al., 2003). The mammalian Gcgr, Glp1r, and Glp2r genes, together with the Palomid 529 for the receptor

• br NLS and NES Mapping br Sequence Comparison of

  2021-12-27

  

  NLS and NES Mapping Sequence Comparison of Gli NLSs—NLSs in ZF Domains Alignment of the Gli NLSs of representative metazoan animals suggests that the amino Homoharringtonine australia residues in the ZF domains are strongly conserved (Figure 4.2, Figure 4.3B). However, the length of the inte

• br Presenilins and apoptosis Apoptosis

  2021-12-24

  

  Presenilins and apoptosis Apoptosis, also known as programmed cell death, has a critically important role in tissue homeostasis, development, normal ageing and the pathogenesis of several diseases, including cancer and neurological disorders. The presenilins were first linked to apoptosis when ce

14471 records 482/965 page Previous Next First page 上5页 481482483484485 下5页 Last page