• Two cases with SERPINE FOSB fusion reported by Walther et

  2020-08-03

  

  Two cases with SERPINE1-FOSB fusion reported by Walther et al. [8] include a case with insertion of 61 nucleotides of SERPINE1 intron 1 between SERPINE exon 1 and FOSB exon 2. This fusion results in formation of putative translation start codon within FOSB exon 2. The other reported case with SERPIN

• These results may indicate the heterogeneity of protein expr

  2020-08-03

  

  These results may indicate the heterogeneity of protein expression and functional mechanisms in tumour. An interesting study analysed the expression of all Eph and Ephrin variants in CRC. In all cases, at least one Eph gene was found in normal colons (EphA1, EphA2, EphB2, and EphB4), the expressions

• In contrast to G and G which are buried Fig

  2020-08-03

  

  In Ion Channel Compound Library to G468 and G469, which are buried (Fig. 7a), residues 470–476 are equivalent to the surface loop L12 present in the crystal structure of the LigI complex (Fig. 7b) [17]. The OBD of DNA ligases adopts at least two distinct orientations during the catalytic cycle. In t

• DNA ligase IV contains a

  2020-08-03

  

  DNA ligase IV contains a conserved ligase domain at its N-terminus and a tandem BRCT domain at its C-terminus (Fig. 1a) [7]. Interaction with Xrcc4 requires the region between the BRCT domains and likely part of the BRCT domain [8], [9]. The DNA ligase IV/Xrcc4 complex is large and its crystal struc

• br Conflict statement br Introduction Prostate cancer PCa is

  2020-08-03

  

  Conflict statement Introduction Prostate cancer (PCa) is the second most frequently diagnosed cancer and the second leading cause of cancer death in men after lung cancer [1], [2]. The incidence and mortality rate of prostate cancer are significantly higher in developed countries especially th

• Our dietary reconstruction relies primarily

  2020-07-31

  

  Our dietary reconstruction relies primarily on collagen data. Considering the impact of local environment on the stable isotope ratios of foodwebs (Herrscher and Le Bras-Goude, 2010; Drucker and Henry-Gambier, 2005; Kinaston et al., 2014), specific attention was paid to characterize the stable carbo

• As for the molecular mechanism Ferguson BD

  2020-07-31

  

  As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines. Treatment of DCPIB synthesis with EphrinB2/Fc induced topoisomerase activity as assessed by DNA relaxation in cells with high EphB4 expression

• Quinolizidine alkaloids which have powerful and

  2020-07-31

  

  Quinolizidine alkaloids, which have powerful and wide pharmacological activities, have been proven to be the main bioactive components in S. flavescens. OSC showed significant anti-HBV activity with inhibitory potency against HBsAg secretion [4] and has significant neuroprotective effects that can b

• Several non mutually exclusive possibilities for how RING bi

  2020-07-31

  

  Several non-mutually exclusive possibilities for how RING binding promotes closed E2~Ub conformations are suggested by the recent RING-type E3:E2~Ub structures. One possibility is through direct RING–ubiquitin interactions. Available structures, however, show that the extent to which the RING direct

• Protein ubiquitination and the ubiquitin proteosome system

  2020-07-31

  

  Protein ubiquitination and the ubiquitin proteosome system (UPS) play a role in many viral infections by targeting viral proteins for degradation or for modification that leads to altered viral protein functions (Alcaide-Loridan and Jupin, 2012, Okumura et al., 2006, Shackelford and Pagano, 2005). V

• Antioxidants such as SFN have been

  2020-07-31

  

  Antioxidants such as SFN have been proposed to be chemopreventive agents to inhibit, delay or reverse the development of cancer (Bayat Mokhtari et al., 2018). SFN was shown in breast epithelial cell culture to suppress oxidative metabolism of E2/E1 and thus protect against estrogen-mediated DNA dama

• Here we present a detailed method for

  2020-07-31

  

  Here we present a detailed method for the preparation of E. coli-produced Ric-8A proteins that are stoichiometrically-phosphorylated using recombinant protein kinase CK2 holoenzyme. The method entails a re-purification step to isolate phosphorylated Ric-8 proteins away from kinase. The phosphorylate

• With respect to the duration of acid etching few studies

  2020-07-30

  

  With respect to the duration of acid-etching, few studies have shown that ceramic etching with a 5% HF during for 2–3 min is sufficient to dissolve the glassy phase [32], increasing roughness and creating a surface more favourable to bonding. Similarly, a previous study [33] showed that 10% hydroflu

• br Lessons from known structures and

  2020-07-30

  

  Lessons from known structures and catalytic mechanisms The catalytic mechanism and molecular mechanisms underlying the regulation of mammalian DGKs is of major interest. This is because this knowledge will not only fill an important gap in our understanding of these enzymes, such information is a

• iniparib br Results br Discussion The current study integrat

  2020-07-30

  

  Results Discussion The current study integrates results from both a new screen in 3D culture and more conventional screens in 2D culture. Screening in 3D culture has the advantage of sensitizing KRAS mutant iniparib to Raf-MEK-ERK pathway inhibition (Figure 1D), so that the phenotypes observed

14761 records 782/985 page Previous Next First page 上5页 781782783784785 下5页 Last page