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To better understand Wolbachia s dependence on these enzymes
2020-01-20
To better understand Wolbachia’s dependence on these enzymes, RNAi experiments targeting these transcripts will be required to examine the consequences of their down-regulation on Wolbachia in the different tissues of the parasite. Initial studies have shown that decreases in Bm-cpl-3 and Bm-cpl-6 t
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Instead of receptor interaction or GT activity
2020-01-20
Instead of receptor interaction or GT activity, we focused on the CPD and autoprocessing. The CPDs from the 2 toxins are highly homologous: each cysteine protease targets an intramolecular substrate and mediates InsP6-induced autoprocessing to release the GTD into host cytosol.40, 41 However, TcdB i
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Although the presence of at least
2020-01-20
Although the presence of at least one triple helix domain is typically the collagen signature, collagens are modular proteins composed of a succession of collagenous (COL) and non-collagenous domains (NC) that are both involved in collagen functions and in receptor binding. COL domains are linked by
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Lavallee et al reported that PREG could be esterified
2020-01-20
Lavallee et al. [30] reported that PREG could be esterified by lecithin:cholesterol acyltransferase (LCAT). LCAT uses cholesterol and phosphatidyl choline present in the newly formed high-density lipoprotein (HDL) as substrates and convert them into cholesteryl esters and lysophosphatidyl choline. T
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br Conclusions br Acknowledgements Implantable Microsystems
2020-01-20
Conclusions Acknowledgements Implantable Microsystems for Personalised Anti-Cancer Therapy is a EPSRC (Engineering and Physical Sciences Research Council, UK) funded grant (Ref. EP/K034510/1) Introduction Flemingia philippinensis, belonging to the legume family, is a polyphenol rich plant
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br Conflict of Interest br Statement of Authorship br
2020-01-19
Conflict of Interest Statement of Authorship Introduction Plant endopeptidases are involved in many important biological processes. Recent developments in molecular biological techniques have revealed trace amounts of endopeptidases play essential roles in plant development, turnover of pho
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To overcome problems with the biochemical reconstitution
2020-01-19
To overcome problems with the biochemical reconstitution of these heterodimeric cytokines fusion strategies linking both subunits together have been proposed inspired by the “hyper-IL-6” [28]. Much like fusing a protein to a solubility enhancing protein such as MBP or SUMO, fusing two subunits of a
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br These component origins have been chosen as they are
2020-01-19
These component origins have been chosen as they STF-118804 synthesis are well-defined options related to developing with components (see for example Morisio and Torchiano (2002); Carney and Long (2000) and Gacek and Arief (2004)). The individual component origins (COTS, OSS, in-house developed c
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Ticlopidine HCl On the one hand levels of up
2020-01-19
On the one hand, levels of up to 20 nM P4 have been reported for a cyprinid species, Labeo rohita, in summer (Suresh et al., 2008). Similarly, P4 concentrations in tilapia, Oreochromis mossambicus, were found to range up to 27 nM (Cornish, 1998). Nevertheless in sturgeon P4 levels of approximately 3
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Estradiol the predominant circulating estrogen in humans it
2020-01-19
Estradiol, the predominant circulating estrogen in humans, it is mainly secreted by the granulosa cells of the ovarian follicles, and the corpora lutea, by the mechanisms indicated above. On the other hand, estretrol is synthesized exclusively during pregnancy by the fetal liver and reaches maternal
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It has previously been shown that human
2020-01-19
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of Calcium Colorimetric Assay Kit on human melanocytes led to inconsistent data [12], [13]. Im et al. [14
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br Results and discussion Analysis of experimental data
2020-01-19
Results and discussion Analysis of experimental data indicates that the radon PEG Virus Precipitation Kit coefficient in OPC blended with RHA varies from 0.15 × 10−6 m2 s−1 for pure cement to 0.26 × 10−6 m2 s−1 for cement mixed with 50% RHA by weight. The value of diffusion coefficient first dec
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Recent reports revealed that CSE affects the endothelial
2020-01-19
Recent reports revealed that CSE affects the endothelial cells of various tissues like kidney, liver, heart including kobe2602 synthesis [26,30]. The damage of brain endothelial cells enhances the progress of cognitive dysfunction due to the accumulation of toxic free bio-radicals and activation of
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Introduction Proteins play an important role in cellular
2020-01-19
Introduction Proteins play an important role in cellular functions; however, being and remaining properly folded is necessary for their function. Understanding the stability of the protein is necessary to investigate the folding of proteins, as well as their conformation, functions and interactions
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The attachment of ubiquitin to RTKs such as
2020-01-19
The attachment of ubiquitin to RTKs, such as EGFR, mediates efficient delivery through the endosome-lysosome system for proteolysis. In this way, RTK degradation enables cessation of signal transduction. A recent siRNA screen identified a number of USPs that can significantly modulate EGFR levels an
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