MuRF1 and MuRF3 in cooperation

2019-07-02

MuRF1 and MuRF3 in cooperation with the E2 ubiquitin-conjugating enzymes UbcH5a, -b, and -c were found to mediate degradation of myosin heavy chain β/slow (MHC β/slow) and MHC IIa via UPS, both, in vitro and in vivo [60]. Mice lacking both MuRF1 and MuRF3 developed skeletal muscle myopathy and hypertrophic cardiomyopathy with sub-sarcolemmal MHC accumulation, myofibril fragmentation and diminished muscle performance, leading to myosin storage myopathy [60].

We examined pharmacologic

2019-07-01

We examined pharmacologic exposures among the subset of women diagnosed with breast cancer on or after 1995 (N=620) and found that over two thirds (70.8%) received adjuvant endocrine therapy prior to hip or BRD4 fracture, including 30.8% who received tamoxifen only, 23.1% who received aromatase inhibitor only, and 16.9% who received both tamoxifen and aromatase inhibitor at some point during the interval between breast cancer diagnosis and subsequent fracture.

There is a lot to celebrate and

2019-06-29

There is a lot to celebrate and applaud in this month\'s issue of , but also some sobering findings and a clear demonstration of the need for more research. To start with the positive, Osman Sankoh and fellow INDEPTH Network colleagues announce a new freely accessible repository of Health and Demographic Surveillance System data generated by its member centres across Africa, Asia, and the Pacific.

To date, over 250 mutations

2019-06-28

To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [5,18,35,36].

The clinical presentation of patients with

2019-06-27

The clinical presentation of patients with CIED pocket infection and those with endovascular infection can vary, but once the diagnosis is made, the management is similar and involves removal of all hardware along with antibiotic therapy [2,7,8,15]. Conservative managements with CCK-8 therapy only carries high failure rate and is associated with increased mortality [9].

Hello world!

2018-07-29